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Avoid prolonged alkaline conditions

Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

Last reviewed: June 12, 2026 Last updated: June 12, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

4.4 Application of non-pharmacological interventions in adjunctive treatment of depression While pharmacological treatment remains the cornerstone of depression management in PLWH, concerns regarding its potential adverse effectssuch as physical discomfort, sexual dysfunction, substance abuse, and overdose-related fatalitiesalong with the interactions between antidepressants and antiretroviral medications, and the risk of withdrawal and rebound phenomena, have prompted increasing interest in non-pharmacological treatments (131, 156)